Information on Ulcerative Colitis
Colitis (also called ulcerative colitis) is an acute or chronic inflammation of the membrane lining the colon—your large intestine or bowel. Colitis causes inflammation and sores, called ulcers, in the top layers of the lining of the large intestine. Ulcerative colitis rarely affects the small intestine except for the lower section, called the ileum.
Colitis means inflammation of the colon. The colon, also known as the large intestine or large bowel, constitutes the last part of the digestive tract. The colon is a long, muscular tube that receives undigested food from the small intestine. It removes water from the undigested food, stores it and then eliminates it from the body through bowel movements. The rectum is the last part of the colon adjacent to the anus. The common symptoms of colitis include:
- abdominal pain,
- diarrhea, and
- sometimes, rectal bleeding.
Ulcerative colitis is closely related to another condition of inflammation of the intestines called Crohn’s disease. Together, they are frequently referred to as inflammatory bowel disease (IBD). Ulcerative colitis and Crohn’s diseases are chronic conditions that can last years to decades. They affect approximately 500,000 to 2 million people In the United States. Men and women are affected equally.
Ulcerative colitis affects the large intestine (also known as the colon) and the rectum. It causes inflammation of the colon’s inner lining and the rectal wall, which become red, swollen, and ulcerated, resulting in abdominal pain or cramping, rectal bleeding, and diarrhea. Less common are fatigue, appetite loss, and anemia. Some people also have joint pain, redness, swelling, and liver problems.
The immune system is composed of immune cells which protects the body from bacteria, fungi and other foreign invaders. In a normal case, exposure of the human body to harmful foreign bodies and parasites leads to the activation of the immune system. But it is not so in the case of a person suffering from ulcerative colitis. Here activation of the immune system takes place in the absence of any known invader. This results in inflammation and ulceration.
Ulcerative colitis can occur in people of any age, but it usually starts between the ages of 15 and 30, and less frequently between 50 and 70 years of age. It affects men and women equally and appears to run in families, with reports of up to 20 percent of people with ulcerative colitis having a family member or relative with ulcerative colitis or Crohn’s disease. A higher incidence of ulcerative colitis is seen in Whites and people of Jewish descent.
Inflammation is a process that occurs when the body’s immune system begins to fight off foreign invaders, such as viruses, bacteria, and fungi. The immune system is a network of organs, tissues, cells, and chemicals designed to kill invading organisms. Some of the chemicals produced by the immune system irritate the body’s own tissues. They cause heat, redness, swelling, and loss of function. These changes are all characteristic of inflamed tissue.
The infection is spread by saliva, urine, respiratory droplets, sexual contact, and blood transfusions. Most humans are exposed to the virus in their lifetime, but it usually produces no symptoms in healthy people. However, serious CMV infections can occur in people with weakened immune systems. This includes patients receiving chemotherapy for cancer treatment and patients on immune-suppressing medicines following an organ transplant.
